Just when you thought you were hardcore...
The more densely packed computing circuitry becomes, the fast it can run, in part because the connection paths are so short. Until room-temperature superconductors are invented, passing an electrical current through a physical connection, no matter how short, will prevent the current from running at the speed of light due to the phenomenon of electrical resistence. Another problem arises as a result of densely packing circuitry: Heat. Lots of heat.
This is a problem that can't really be eliminated, because heat is a natural manifestation of entropy. When you lose decoherence in anything for any reason waste heat is generated …
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